Mark Peakman Selected Research

preproinsulin

1/2018	Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.
1/2018	Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells.
4/2016	Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.
1/2013	Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.
7/2012	Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.
1/2012	Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
10/2008	CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

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Mark Peakman Research Topics

Disease

61	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 06/2002
15	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 12/2004
6	Infections 01/2020 - 07/2003
4	Neoplasms (Cancer) 01/2018 - 12/2013
4	Inflammation (Inflammations) 10/2017 - 05/2012
4	Disease Progression 04/2016 - 04/2012
3	Communicable Diseases (Infectious Diseases) 03/2016 - 04/2006
2	Human Influenza (Influenza) 01/2017 - 03/2016
2	Insulinoma 04/2016 - 08/2011
2	Anthrax 07/2006 - 12/2005
2	Plague (Bubonic Plague) 07/2006 - 12/2005
2	Whooping Cough (Pertussis) 07/2006 - 12/2005
1	Hypoglycemia (Reactive Hypoglycemia) 01/2021
1	Infectious Mononucleosis (Glandular Fever) 01/2020
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020
1	Cognitive Dysfunction 01/2019
1	Psychotic Disorders (Schizoaffective Disorder) 01/2019
1	Ankylosing Spondylitis 01/2018
1	Ketosis 01/2018
1	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2017
1	Celiac Disease (Celiac Sprue) 01/2014
1	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2013
1	Tertiary Lymphoid Structures 09/2010
1	Hypersensitivity (Allergy) 03/2009
1	Hyperglycemia 10/2008
1	Tetanus 07/2006
1	Diphtheria 07/2006

Drug/Important Bio-Agent (IBA)

19	AntigensIBA 01/2022 - 06/2002
19	Peptides (Polypeptides)IBA 01/2022 - 02/2004
16	Insulin (Novolin)FDA Link 01/2022 - 10/2008
15	AutoantigensIBA 01/2022 - 12/2004
13	EpitopesIBA 01/2021 - 12/2004
7	preproinsulinIBA 01/2018 - 10/2008
7	CytokinesIBA 10/2017 - 07/2003
6	ProinsulinIBA 01/2022 - 10/2006
6	AutoantibodiesIBA 12/2019 - 01/2009
4	HLA Antigens (Human Leukocyte Antigens)IBA 01/2020 - 01/2012
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2010
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2020 - 09/2015
3	Abatacept (Orencia)FDA Link 01/2020 - 04/2014
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 08/2011
3	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2018 - 04/2016
3	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 10/2008
3	Interleukin-10 (Interleukin 10)IBA 05/2012 - 01/2005
2	HLA-A*02:01 antigenIBA 01/2020 - 01/2012
2	AntibodiesIBA 01/2019 - 01/2016
2	HLA-A Antigens (HLA-A)IBA 01/2018 - 01/2018
2	Indicators and Reagents (Reagents)IBA 01/2018 - 09/2015
2	Protein Sorting Signals (Signal Peptide)IBA 01/2018 - 07/2012
2	HLA-DQ Antigens (HLA-DQ)IBA 11/2017 - 01/2014
2	InterleukinsIBA 10/2017 - 08/2011
2	Therapeutic UsesIBA 10/2014 - 04/2006
2	HLA-A24 AntigenIBA 01/2013 - 07/2012
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 10/2007 - 07/2003
2	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 10/2007 - 07/2003
2	Interleukin-8 (Interleukin 8)IBA 10/2007 - 07/2003
2	Interleukin-6 (Interleukin 6)IBA 10/2007 - 07/2003
2	VaccinesIBA 07/2006 - 12/2005
1	HLA-DRB1*04:01 antigenIBA 01/2022
1	InterferonsIBA 01/2022
1	tyramine-deoxysorbitolIBA 01/2020
1	Biological ProductsIBA 01/2020
1	aluminum sulfate (alum)IBA 01/2020
1	Immunodominant EpitopesIBA 01/2018
1	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 01/2018
1	Zinc Transporter 8IBA 01/2018
1	HLA-B Antigens (HLA-B)IBA 01/2018
1	Complementarity Determining Regions (Complementarity Determining Region)IBA 11/2017
1	Pharmaceutical PreparationsIBA 01/2017
1	HLA-DR3 Antigen (HLA DR3 Antigen)IBA 04/2016
1	Protein Isoforms (Isoforms)IBA 04/2016
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 04/2016
1	Histocompatibility Antigens Class IIIBA 01/2016
1	Coloring Agents (Dyes)IBA 09/2015
1	C-PeptideIBA 10/2014
1	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2014
1	Glutens (Glutelin)IBA 01/2014
1	Sirolimus (Rapamycin)FDA Link 08/2013
1	Drug CombinationsIBA 08/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2013
1	HLA-A2 Antigen (HLA A2 Antigen)IBA 01/2013
1	Interleukin-2 (IL2)IBA 05/2012
1	RNA (Ribonucleic Acid)IBA 09/2011
1	Interleukin-17 (Interleukin 17)IBA 08/2011
1	EnzymesIBA 08/2011
1	Omalizumab (Xolair)FDA Link 03/2009
1	Rituximab (Mabthera)FDA Link 03/2009
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2009
1	adenovirus receptorIBA 10/2007
1	ChemokinesIBA 10/2007
1	lymphotactinIBA 10/2007
1	Integrin beta3 (GPIIIa)IBA 10/2007
1	ToxoidsIBA 07/2006

Therapy/Procedure

16	Immunotherapy 01/2022 - 02/2004
12	Therapeutics 01/2021 - 04/2006
3	Islets of Langerhans Transplantation 01/2021 - 08/2013
1	Glycemic Control 01/2020
1	Precision Medicine 01/2019
1	Cell Transplantation 01/2016
1	Withholding Treatment 04/2014